Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer
| Autor: | Bríd M, Ryan, Krista A, Zanetti, Ana I, Robles, Aaron J, Schetter, Julie, Goodman, Richard B, Hayes, Wen-Yi, Huang, Mark J, Gunter, Meredith, Yeager, Laurie, Burdette, Sonja I, Berndt, Curtis C, Harris |
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| Rok vydání: | 2013 |
| Předmět: |
Adenoma
Male Genotype Blotting Western Apoptosis Real-Time Polymerase Chain Reaction Polymorphism Single Nucleotide Article Cell Movement Risk Factors Biomarkers Tumor Cell Adhesion Humans RNA Messenger Early Detection of Cancer Germ-Line Mutation Aged Cell Proliferation Neoplasm Staging Reverse Transcriptase Polymerase Chain Reaction Cell Cycle NADPH Oxidases Cell Differentiation Middle Aged Prognosis Immunity Innate Case-Control Studies Female Colorectal Neoplasms NADP Follow-Up Studies |
| Zdroj: | International journal of cancer. 134(6) |
| ISSN: | 1097-0215 |
| Popis: | Chronic inflammation has been implicated in the etiology of colorectal adenoma and cancer; however, few key inflammatory genes mediating this relationship have been identified. In this study, we investigated the association of germline variation in innate immunity genes in relation to the risk of colorectal neoplasia. Our study was based on the analysis of samples collected from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. We investigated the association between 196 tag single nucleotide polymorphisms (SNPs) in 20 key innate immunity genes with risk of advanced colorectal adenoma and cancer in 719 adenoma cases, 481 cancer cases and 719 controls. Logistic regression was used to estimate odds ratios and 95% confidence intervals. After Bonferroni correction, the AG/GG genotype of rs5995355, which is upstream of NCF4, was associated with an increased risk of colorectal cancer (odds ratio [OR] 2.43, 95% confidence interval [95% CI] 1.73 – 3.39; P |
| Databáze: | OpenAIRE |
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