| Autor: |
Saverio, Ligato, Wieslaw, Furmaga, Richard W, Cartun, David, Hull, Gregory J, Tsongalis |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Oncology reports. 13(3) |
| ISSN: |
1021-335X |
| Popis: |
We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interest because in addition to the morphological and cytological features of a typical carcinoid, it demonstrated a distinct pleomorphic area immunoreactive for gastrin. By molecular analysis, loss of heterozygosity (LOH) with opposite allelic patterns between the gastrin-positive and gastrin-negative areas of the tumor was identified. The molecular studies for LOH along with the morphology and IHC profiling suggest that this second population of gastrin-positive carcinoid cells may represent a new clone within the carcinoid tumor with differentiation toward gastrin production or may represent the next step in the carcinogenic process with a gradual emergence of a more aggressive clone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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