Serotonin
| Autor: | Ai, Nagata, Kiyomi, Nakayama, Shiro, Nakamura, Ayako, Mochizuki, Chikako, Gemba, Risa, Aoki, Masanori, Dantsuji, Koutaro, Maki, Tomio, Inoue |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Motor Neurons Serotonin Patch-Clamp Techniques Masseter Muscle Mandibular Nerve Presynaptic Terminals Excitatory Postsynaptic Potentials Glutamic Acid Proprioception Receptors Presynaptic Synaptic Transmission Electric Stimulation Rats Serotonin Receptor Agonists Inhibition Psychological Receptor Serotonin 5-HT1B Animals Female Serotonin Antagonists Rats Wistar Brain Stem |
| Zdroj: | Brain research bulletin. 149 |
| ISSN: | 1873-2747 |
| Popis: | The proprioceptive sensory inputs from neurons in the mesencephalic trigeminal nucleus (MesV) to masseter motoneurons (MMNs) play an important role in regulating masseter muscle activity during mastication. Several histological studies have shown that serotonin (5-HT) fibers densely innervate both the MesV and the trigeminal motor nucleus. However, the functional roles of 5-HT in the regulation of the excitatory synaptic inputs from MesV afferents to MMNs remain to be clarified. Thus, using the whole-cell recording technique in brainstem slice preparations from juvenile Wistar rats aged between postnatal days 8 and 12, we examined the effects of 5-HT on the excitatory synaptic inputs from MesV afferents to MMNs. Bath application of 5-HT reduced the peak amplitude of excitatory postsynaptic potentials evoked in MMNs by electrical stimulation of the MesV afferents (eEPSPs), and this inhibitory effect of 5-HT on eEPSPs was replicated with the 5-HT |
| Databáze: | OpenAIRE |
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