Changes in the number of polymorphonuclear leukocytes and concentrations of IL-8 and granulocyte elastase in the vaginas of normal pregnant women

Autor:	Tetsuo, Yamada, Hisanori, Minakami, Shigeki, Matsubara, Yasuhiro, Kohmura, Toshio, Aoya, Ikuo, Sato
Rok vydání:	2002
Předmět:	Adult Leukocyte Count Neutrophils Pregnancy Interleukin-8 Vagina Humans Female Leukocyte Elastase
Zdroj:	American journal of reproductive immunology (New York, N.Y. : 1989). 47(2)
ISSN:	1046-7408
Popis:	It is unknown whether the number of vaginal polymorphonuclear leukocytes (vPMNs) of healthy pregnant women changes during pregnancy.We studied 23 women after 14.7 +/- 3.6 weeks, 37 women after 25.2 +/- 3.1 weeks, and 26 women after 32.9 +/- 2.0 weeks of gestation. Numbers of total vPMNs, viable vPMNs, dead vPMNs, percentage viability of vPMNs, and concentrations of IL-8 and elastase activity were determined in vaginal washings.The vPMNs, including viable and dead vPMNs, significantly increased with advancing gestation from 9.9 +/- 8.6 x 10(5) to 13.1 +/- 13.4 x 10(5), and to 27.1 +/- 26.6 x 10(5) (r=0.315, P0.01). Vaginal IL-8 significantly increased with advancing gestation. However, increases in vaginal elastase activity did not occur.These results suggested that an increase in vPMNs is an early event, and that the increase in vaginal elastase activity is a late event in relation to the ripening of the uterine cervix.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2719e46ae2562e76f106d27d822793fc https://pubmed.ncbi.nlm.nih.gov/11900594 Zobrazit plný text záznamu Plný text