| Autor: |
T, Shestakova, E, Zhuravel, L, Bolgova, S, Zaitsev, O, Efanova, M, Soldatkina, P, Pogrebnoy |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Experimental oncology. 32(4) |
| ISSN: |
1812-9269 |
| Popis: |
The present research was directed on analysis of the expression patterns of human beta-defensin-2 (hBD-2) in human lung tumors.Specimens of surgically resected human lung tumors (n = 31) of different histological type (1 case of small cell lung cancer, and 30 cases of non-small cell lung cancer (1 case of clear cell carcinoma, 9 cases of squamous cell carcinoma (SCC), and 20 cases of adenocarcinoma (AC)) were analyzed for expression of hBD-2 with the use of immunohistochemical analysis.Immunohistochemical analysis has revealed that all lung tumor samples independently on their histological type express hBD-2 peptide, however at different levels (from5% to 100% cells). According to our observations, low-differentiated AC differs from moderately differentiated AC by significantly lower hBD-2 expression levels (p0.05). No correlation between hBD-2 expression patterns and PCNA or Bcl-2 expression has been found.Human beta-defensin-2 expression levels may depend on differentiation grade of lung adenocarcinoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
