| Autor: |
Figueroa-Valverde, Lauro, Lopez-Ramos, Maria, Lopez-Gutierrez, Tomas, Diaz Cedillo, Francisco, Garcia-Martinez, Rolando, Rosas-Nexticapa, Marcela, Mateu-Armand, Virginia, Garcimarero-Espino E, Alejandra, Ortiz-Ake, Yazmin |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Steroids. 158 |
| ISSN: |
1878-5867 |
| Popis: |
Several drugs have been prepared to treat of heart failure using some protocols which require dangerous reagents and specific conditions. The aim of this study was to synthesize a series of steroid derivatives (compounds 2 to 18) using some chemical strategies. The biological activity of steroid derivatives against heart failure was evaluated using an ischemia/reperfusion model. In addition, the effect exerted by compounds 4 or 5 on left ventricular pressure was evaluated in the absence or presence of yohimbine, butaxamine and methoctramine. The results showed that 1) both compounds 4 or 5 significantly decrease the heart failure (translated as infarct area) compared with the compounds 2, 3 and 6-18. In addition, the compound 4 and 5 decreased the left ventricular pressure in a dose-dependent manner and this effect was significantly inhibited in the presence of methoctramine (p = 005). In conclusion, the compounds 4 or 5 decrease both the infarct area and left ventricular pressure via M |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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