| Autor: |
G H, Kamimori, R W, Hoyt, N D, Eddington, P M, Young, M J, Durkot, V A, Forte, A E, Brunhart, S, Lugo, A, Cymerman |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Aviation, space, and environmental medicine. 66(3) |
| ISSN: |
0095-6562 |
| Popis: |
The pharmacokinetics of caffeine and cardio-green (ICG) were examined in four micro swine at sea level (SEA) and following 21 d continuous exposure to 4600 m (ALT) in a hypobaric chamber. Caffeine (84.7 mg) and ICG (10 mg) were administered as separate intravenous boluses and sequential blood samples collected.Caffeine clearance significantly (p0.05) increased in ALT (96.8 +/- 20.0 ml.min-1) as compared to SEA (53.6 +/- 24.8 ml.min-1), demonstrating that liver function increased in ALT. There was no significant change in the ratio of primary metabolites to caffeine, suggesting that the increase in clearance was not due to a change in the rate of caffeine metabolism. ICG clearance significantly increased in ALT (179.8 +/- 57.4 ml.min-1) as compared to SEA (84.4 +/- 28.9 ml.min-1) indicating that hepatic blood flow (HBF) increased.These results demonstrate that chronic exposure to 4600 m increases the clearance of caffeine and ICG in the micro swine model and suggests that the increase in caffeine clearance is related to HBF. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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