Cytosine arabinoside and cisplatin for advanced breast cancer. A phase II study of the Cancer and Leukemia Group B

Autor:	M W, Oster, R L, Schilsky, D, Faraggi, A H, Korzun, M, Perry, A, Moore, J, Kalra, W C, Wood, I C, Henderson
Rok vydání:	1991
Předmět:	Adult Survival Rate Antineoplastic Combined Chemotherapy Protocols Cytarabine Drug Evaluation Humans Breast Neoplasms Female Prospective Studies Cisplatin Middle Aged Drug Administration Schedule Aged
Zdroj:	Cancer. 68(8)
ISSN:	0008-543X
Popis:	Forty-four women with advanced breast cancer participated in a prospective clinical trial to evaluate the efficacy and toxicity of a regimen consisting of cytosine arabinoside and cisplatin. All patients had previously received chemotherapy. Three patients (7%) responded to therapy with response durations of 153, 160, and 441 days. The median time to disease progression and median survival time in all 44 patients were 2.3 and 5 months, respectively. This regimen had significant toxicity, with most patients experiencing severe or life-threatening hematologic, renal, or infectious complications. This regimen cannot be recommended for previously treated patients with advanced breast cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::26caac044ccc546dfc788d29cb009acd https://pubmed.ncbi.nlm.nih.gov/1913511 Zobrazit plný text záznamu Plný text