| Autor: |
Iu O, Fedotova, N S, Sapronov |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 76(12) |
| ISSN: |
0869-2092 |
| Popis: |
We have studied the effect of stimulation or blockade of the 5-HT(1A) receptors on the passive avoidance performance and open-field test behavior in gonadectomized (GDX) male rats of middle age treated with a low dose of testosterone propionate. of The 5-HT(1A) receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) or 5-HT(1A) receptor antagonist NAN-190 (0.1 mg/kg, i.p.) were chronically (for 14 days) administered alone and in a combination with low dose of testosterone propionate (0.5 mg/kg, s.c.) in GDX rats of middle age (12 - 15 months). The co-administration of NAN-190 with low dose of testosterone propionate completely restored impaired passive avoidance performance in GDX males of middle age. Moreover, GDX rats of middle age treated with NAN-190 and low dose of testosterone propionate demonstrated increased exploratory and grooming behavior in the open-field test. Both 8-OH-DPAT alone and in combination with low dose of testosterone propionate markedly impaired passive avoidance learning and failed to modify behavior in the open-field test in GDX rats of middle age. The results of the present study are indicative of a positive effect of NAN-190 in combination with low dose of testosterone propionate on the passive avoidance learning at androgen deficiency in male rats of middle age. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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