| Autor: |
Alexander, Peidl, John, Nguyen, Pratyusha, Chitturi, Bruce L, Riser, Andrew, Leask |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Methods in molecular biology (Clifton, N.J.). 2582 |
| ISSN: |
1940-6029 |
| Popis: |
Approximately 45% of the deaths in the developed world result from conditions with a fibrotic component. Although no specific, focused anti-fibrotic therapies have been approved for clinical use, a long-standing concept is that targeting CCN proteins may be useful to treat fibrosis. Herein, we summarize current data supporting the concept that targeting CCN2 may be a viable anti-fibrotic approach to treat scleroderma. Testing this hypothesis has been made possible by using a mouse model of inflammation-driven skin and lung fibrosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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