Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride

Autor:	V, Abitbol, J Y, Mary, C, Roux, J C, Soulé, J, Belaiche, J-L, Dupas, J P, Gendre, E, Lerebours, S, Chaussade
Rok vydání:	2002
Předmět:	Adult Male Reproducibility of Results Inflammatory Bowel Diseases Body Mass Index Phosphates Fluorides Absorptiometry Photon Double-Blind Method Adrenal Cortex Hormones Bone Density Humans Osteoporosis Calcium Drug Therapy Combination Female Vitamin D
Zdroj:	Alimentary pharmacologytherapeutics. 16(5)
ISSN:	0269-2813
Popis:	Previous data have indicated low bone formation as a mechanism of osteoporosis in inflammatory bowel disease. Fluoride can stimulate bone formation.To assess the effect of fluoride supplementation on lumbar spine bone mineral density in osteoporotic patients with inflammatory bowel disease treated in parallel with calcium and vitamin D.In this prospective, randomized, double-blind, parallel and placebo-controlled study, 94 patients with inflammatory bowel disease (lumbar spine T score below - 2 standard deviations, normal serum 25OH vitamin D), with a median age of 35 years, were included. Bone mineral density was measured by dual-energy X-ray absorptiometry. Patients were randomized to receive daily either sodium monofluorophosphate (150 mg, n=45) or placebo (n=49) for 1 year, and all received calcium (1 g) and vitamin D (800 IU). The relative change in bone mineral density from 0 to 12 months was tested in each group (fluoride or placebo) and compared between the groups.Lumbar spine bone mineral density increased significantly in both groups after 1 year: 4.8 +/- 5.6% (n=29) and 3.2 +/- 3.8% (n=31) in the calcium-vitamin D-fluoride and calcium-vitamin D-placebo groups, respectively (P0.001 for each group). There was no difference between the groups (P=0.403). Similar results were observed according to corticosteroid intake or disease activity.Calcium and vitamin D seem to increase lumbar spine density in osteoporotic patients with inflammatory bowel disease; fluoride does not provide further benefit.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::269a5428956de9c8e87325a67e646fc6 https://pubmed.ncbi.nlm.nih.gov/11966500 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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