| Autor: |
Xiao-Meng, Wang, Tong, Zhao, Xiang, Cheng, Ning, Guo, Ling-Ling, Zhu, Ming, Shi, Kui-Wu, Wu |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 34(1) |
| ISSN: |
1000-6834 |
| Popis: |
To investigate the effects of deficiency of CHL1 in inflammatory bowel disease (IBD).Dextran Sulfate Sodium (DSS)-induced colitis model was used to study the effects of deficiency of CHL1 on the development of IBD. Ten CHL1(+/+) mice in C57/BL6 background were randomly divided into CHL1(+/+) group and DSS-induced CHL1(+/+) group. Ten CHL1(-/-) mice in C57/BL6 background were randomly divided into CHL1(-/-) group and DSS-induced CHL1(-/-) group. DSS-induced CHL1(+/+) group and DSS-induced CHL1(-/-)group were fed with 1.5% DSS for 7 days, and then drinking distilled water for 2 days. CHL1(+/+) group and CHL1(-/-) group as control group were fed with distilled water for 9 days. The changes of weight, survival, fecal blood and the change of colon length in this study were observed.On the 7The loss of CHL1 aggravates the development of IBD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
