Syntheses of [14C]-labeled 2-(3-chlorophenyloxy)-3-[3-(3-hydroxy) pyridin-4-yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites

Autor: Takeshi, Ochi, Yusuke, Sawayama, Motoji, Kawasaki, Tomohiro, Nigo, Masashi, Nakao, Tomoki, Omodani, Takaaki, Sumiyoshi
Rok vydání: 2014
Předmět:
Zdroj: Journal of labelled compoundsradiopharmaceuticals. 57(7)
ISSN: 1099-1344
Popis: We describe here the synthesis of [(14)C]-2-(3-chlorophenyloxy)-3-[3-(3-hydroxy)pyridin-4-yl propoxy]pyridine (1), a phosphodiesterase 4 inhibitor. [(14)C]-Labeled 1 was prepared in three steps from [(14)C]-2-bromopyridin-3-ol in an overall yield of 32%. Preparation of [(14)C]-labeled 2 and 3, two metabolites of 1, is also described.
Databáze: OpenAIRE