Autor: |
Takeshi, Ochi, Yusuke, Sawayama, Motoji, Kawasaki, Tomohiro, Nigo, Masashi, Nakao, Tomoki, Omodani, Takaaki, Sumiyoshi |
Rok vydání: |
2014 |
Předmět: |
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Zdroj: |
Journal of labelled compoundsradiopharmaceuticals. 57(7) |
ISSN: |
1099-1344 |
Popis: |
We describe here the synthesis of [(14)C]-2-(3-chlorophenyloxy)-3-[3-(3-hydroxy)pyridin-4-yl propoxy]pyridine (1), a phosphodiesterase 4 inhibitor. [(14)C]-Labeled 1 was prepared in three steps from [(14)C]-2-bromopyridin-3-ol in an overall yield of 32%. Preparation of [(14)C]-labeled 2 and 3, two metabolites of 1, is also described. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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