Immunocytochemical study of NA+ K(+)-ATPase alpha 1 and beta 1 subunits in human and rat normal hepatocytes using confocal microscopy

Autor: L, Benkoël, A M, Benoliel, J, Brisse, B, Sastre, P, Bongrand, A, Chamlian
Rok vydání: 1995
Předmět:
Zdroj: Cellular and molecular biology (Noisy-le-Grand, France). 41(4)
ISSN: 0145-5680
Popis: Hepatic Na+ K(+)-ATPase was recently shown to be composed of two alpha 1 and beta 1 subunits similar to that of kidney. Its localization on hepatocyte plasma membranes was not clearly established. We have studied the localization of alpha 1 and beta 1 subunits using immunocytochemical method and confocal microscopy. In accordance with previous cytochemical findings, the catalytic alpha 1 subunit was distributed in basolateral and bile canalicular membranes of hepatocytes. The beta 1 subunit was not demonstrated, due to its very low amount in the liver. The controversy about the bile canalicular localization was discussed.
Databáze: OpenAIRE