[Pharmacological activity of runihol and S-adenosyl-L-methionine in rats with experimental liver damage by reserve antituberculosis drugs]

Autor:	D S, Sukhanov, T I, Vinogradova, N V, Zabolotnykh, S V, Okovityĭ, S N, Vasil'eva, M L, Vitovskaia
Rok vydání:	2014
Předmět:	Male S-Adenosylmethionine Taurine Antitubercular Agents Succinic Acid Bilirubin Protective Agents Aminosalicylic Acid Inosine Rats Cholesterol Methionine Liver Cycloserine Prothionamide Animals Outbred Strains Hepatocytes Animals Chemical and Drug Induced Liver Injury Triglycerides
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 76(9)
ISSN:	0869-2092
Popis:	The hepatoprotective action of runihol and S-adenosyl-L-methionine (ademethionine) has been studied in a group of 47 white outbred male rats with model liver injury induced by reserve antituberculosis drugs (PAS, prothionamide, cycloserine). The ability of test drugs to correct structural and functional liver disorders is established. Both runihol and ademethionine favored decrease in the signs of structural and functional liver disorders induced by reserve antituberculosis drugs, Showing mixed type of action, the test drugs promoted recovery of the liver parenchyma and reduced manifestations of hepatocyte dystrophy to the same extent, without manifestations of necrobiotic processes and a mononuclear infiltration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2655a8a98976f50c5769ee98adf997a9 https://pubmed.ncbi.nlm.nih.gov/24432566 Zobrazit plný text záznamu