Pasteurella multocida toxin induces IL-6, but not IL-1 alpha or TNF alpha in fibroblasts

Autor:	S, Rosendal, P L, Frandsen, J P, Nielsen, R, Gallily
Rok vydání:	1995
Předmět:	Mice Bacterial Proteins Interleukin-6 Tumor Necrosis Factor-alpha Bacterial Toxins Animals 3T3 Cells Fibroblasts Nitric Oxide Interleukin-1 Research Article
Zdroj:	Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 59(2)
ISSN:	0830-9000
Popis:	Pasteurella multocida toxin (PMT) is the major virulence factor in Progressive Atrophic Rhinitis of swine. Other workers' previous findings that PMT was mitogenic for 3T3 fibroblasts, were confirmed in the present study. In addition, PMT stimulated 3T3 cells to release IL-6, but IL-1 alpha or TNF alpha were not detected in fibroblast supernatants sampled 24, 48, or 72 h after stimulation. In view of the role of IL-6 in osteoclastic bone resorption, these findings provide a new working hypothesis for investigations into the molecular pathogenesis of this important disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::262c0dfbf40f805e06d73dd8ca462071 https://pubmed.ncbi.nlm.nih.gov/7648529 Zobrazit plný text záznamu