| Autor: |
Su-Xian, Zhao, Wen-Cong, Li, Na, Fu, Guang-de, Zhou, Shu-Hong, Liu, Li-Na, Jiang, Yu-Guo, Zhang, Rong-Qi, Wang, Yue-Min, Nan, Jing-Min, Zhao |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Cellular and Molecular Medicine |
| ISSN: |
1582-4934 |
| Popis: |
Primary biliary cholangitis (PBC) is an autoimmune disease characterized by chronic destruction of the bile ducts. A major unanswered question regarding the pathogenesis of PBC is the precise mechanisms of small bile duct injury. Emperipolesis is one of cell‐in‐cell structures that is a potential histological hallmark associated with chronic hepatitis B. This study aimed to clarify the pathogenesis and characteristics of emperipolesis in PBC liver injury. Sixty‐six PBC patients, diagnosed by liver biopsy combined with laboratory test, were divided into early‐stage PBC (stages I and II, n = 39) and late‐stage PBC (stages III and IV, n = 27). Emperipolesis was measured in liver sections stained with haematoxylin‐eosin. The expressions of CK19, CD3, CD4, CD8, CD20, Ki67 and apoptosis of BECs were evaluated by immunohistochemistry or immunofluorescence double labelling. Emperipolesis was observed in 62.1% of patients with PBC, and BECs were predominantly host cells. The number of infiltrating CD3+ and CD8+ T cells correlated with the advancement of emperipolesis (R 2 = 0.318, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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