Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome

Autor:	Ibtissem, Rahim, Ramy K, Sayed, Marisol, Fernández-Ortiz, Paula, Aranda-Martínez, Ana, Guerra-Librero, José, Fernández-Martínez, Iryna, Rusanova, Germaine, Escames, Bahia, Djerdjouri, Darío, Acuña-Castroviejo
Rok vydání:	2020
Předmět:	Mice Knockout Cardiotonic Agents Inflammasomes NF-E2-Related Factor 2 Myocardium Cell Respiration Apoptosis Mitochondria Heart Mice Inbred C57BL Heart Injuries Sepsis NLR Family Pyrin Domain-Containing 3 Protein Animals Female Tumor Suppressor Protein p53 Oxidoreductases Melatonin
Zdroj:	Naunyn-Schmiedeberg's archives of pharmacology. 394(2)
ISSN:	1432-1912
Popis:	Melatonin improved the outcome of septic cardiomyopathy by inhibiting NLRP3 priming induced by reactive oxygen species. To get insights into these events, we studied the melatonin/Nrf2 antioxidant pathways during sepsis in the heart of NLRP3-deficient mice. Sepsis was induced by cecal ligation and puncture and melatonin was given at a dose of 30 mg/kg. Nuclear turnover of Nrf2 and p-Ser40 Nrf2 and expression of ho-1 were enhanced in nlrp3
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::26182a5eb60e92b432654fd169c75c33 https://pubmed.ncbi.nlm.nih.gov/32936353 Zobrazit plný text záznamu Full text from SpringerLink