| Autor: |
Hwan, Lee, Dong-Sung, Lee, Kyung Ja, Chang, Sung Hoon, Kim, Sun Hee, Cheong |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Advances in experimental medicine and biology. 1155 |
| ISSN: |
0065-2598 |
| Popis: |
We want to find the anti-neuroinflammatory action of the taurine derivative Glucose-Taurine Reduced (G-T-R). The anti-neuroinflammatory action by G-T-R were investigated in lipopolysaccharide (LPS)-induced BV2 microglia. G-T-R inhibited the production of nitric oxide and prostaglandin E2, and down-regulated the protein expression of inducible NO synthase and cyclooxygenase-2. In addition, G-T-R reduced the cytokines secretion such as tumor necrosis factor (TNF-α), interleukin (IL) -1β and IL-6, in BV2 microglia treated with LPS. In addition, G-T-R dose-dependently decreased the activation of nuclear factor-kappa B. These findings confirmed the anti-neuroinflammatory activity of G-T-R, which may exert protective effects against neuroinflammatory-related diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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