Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease

Autor: Hwang, Yun Tae, Rocchi, Lorenzo, Hammond, Paul, Hardy, Chris JD., Warren, Jason D., Ridha, Basil H., Rothwell, John, Rossor, Martin N.
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Alzheimer's & Dementia : Translational Research & Clinical Interventions
ISSN: 2352-8737
Popis: Introduction There is a need for a reliable, noninvasive biomarker for Alzheimer's disease (AD). We assessed whether short-latency afferent inhibition (SAI), a transcranial magnetic stimulation paradigm that assesses cholinergic circuits of the brain, could become such a biomarker. Methods Nineteen patients with AD underwent four SAI testing sessions. The timing of their usual donepezil dose was altered to create different cholinergic states for each session. This was compared to the SAI results from 20 healthy subjects. Results SAI was not able to distinguish the different cholinergic states assessed in our study. There appeared to be a diurnal variation in cholinergic function in the control group, which was not present in the AD cohort. Discussion SAI does not appear to have a role in diagnosis and assessment of AD patients. The loss of diurnal variation, however, warrants further investigation as it may provide further biochemical insights about AD.
Highlights • Transcranial magnetic stimulation is unable to differentiate various cholinergic states in Alzheimer's disease patients on donepezil. • Chronic donepezil therapy may induce neuroplastic changes in hippocampal neurons. • A diurnal variation in cholinergic activity may be present in healthy people. • Alzheimer's disease may lead to loss of this diurnal cholinergic activity variation.
Databáze: OpenAIRE
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