Autophagy-related gene
| Autor: | Longxiang, Xie, Huimin, Li, Lu, Zhang, Xiaoyu, Ma, Yifang, Dang, Jinshuai, Guo, Jiahao, Liu, Linna, Ge, Fangmei, Nan, Huan, Dong, Zhongyi, Yan, Xiangqian, Guo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
autophagy diagnostic biomarker Gene Expression Profiling Procollagen-Proline Dioxygenase Protein Disulfide-Isomerases Computational Biology Reproducibility of Results Kaplan-Meier Estimate Prognosis KIRC Kidney Neoplasms P4HB ROC Curve Recurrence Databases Genetic Biomarkers Tumor Humans Female Gene Regulatory Networks prognostic biomarker Carcinoma Renal Cell Neoplasm Staging Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Autophagy can protect cells and organisms from stressors such as nutrient deprivation, and is involved in many pathological processes including human cancer. Therefore, it is necessary to investigate the role of autophagy-related genes (ARGs) in cancer. In this study, we investigated the gene expression of 222 ARGs in 1048 Kidney Renal Clear Cell Carcinoma (KIRC) cases, from 5 independent cohorts. The gene expression of ARGs were first evaluated in the The Cancer Genome Atlas (TCGA) by Recevier Operating Characteristic (ROC) analysis to select potential biomarkers with extremely high ability in KIRC detection (AUC≥0.85 and p |
| Databáze: | OpenAIRE |
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