Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A

Autor: Daniëlle, Copmans, Mostafa, Rateb, Jioji N, Tabudravu, Mercedes, Pérez-Bonilla, Nina, Dirkx, Riccardo, Vallorani, Caridad, Diaz, José, Pérez Del Palacio, Alan J, Smith, Rainer, Ebel, Fernando, Reyes, Marcel, Jaspars, Peter A M, de Witte
Rok vydání: 2018
Předmět:
Zdroj: ACS chemical neuroscience. 9(7)
ISSN: 1948-7193
Popis: In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further development. Within the framework of this project, seven known heterospirocyclic γ-lactams, namely, pseurotin A, pseurotin A
Databáze: OpenAIRE