| Autor: |
Chiraz Nasr, Ben Ammar, Dorra, Mnif, Bacem, Belghith, Lotfi, Kochbati, Hatem, Frikha, Walid, Gargouri, Mounir, Besbes, Mansour, Ben Abdallah, Mongi, Maalej |
| Jazyk: |
francouzština |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
La Tunisie medicale. 88(10) |
| ISSN: |
0041-4131 |
| Popis: |
the tumours of the pineal region are rare brain tumours, most common in children and characterized by a large clinical and histologic polymorphism.to assess the outcome and prognostic factors of 40 patients with primitive pineal region tumours treated at the department of radiotherapy of Salah Azaiz institute.between January 1977 and December 2000, 40 patients received radiotherapy. There were 22 adults and 18 children (age16 years). The mean age was 20.4 years and sex ratio was 2.07. Histologic diagnosis was confirmed in 11 cases; 16 patients had a CT evaluation after 20 Gy radiotherapy and in 13 cases diagnosis was performed with CT aspects ± germinal tumour markers. Target volume varied; 10 had craniospinal irradiation, 16 had local irradiation and 14 had whole brain irradiation with a boost at the tumour bed. Chemotherapy was proposed for metastases and recurrent diseases.survival rates were 87% at 2 years and 74, 5% at 5 years. For children, survival rates were 88% at 2 and 4 years. Eight patients (20%) failed locally and 5 patients (12.5%) had metastasis. Age, performance status and large fields of radiotherapy seem to be associated with prognosis and survival.Pineal tumours and especially germinal tumours are chemosensitive and radiosensitive, care of these tumours is multidisciplinary involving surgery, chemotherapy and radiotherapy. From our study and a review of the literature, we tried to find a therapeutic strategy for tumours of the pineal region. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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