| Autor: |
M, Sposito, F, Truffarelli, I, Sabalich, G, De Giorgi, L, Cova, R, Britta, S, Rufini |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
La Pediatria medica e chirurgica : Medical and surgical pediatrics. 15(1) |
| ISSN: |
0391-5387 |
| Popis: |
Evaluation of growth hormone dependent IGFBP3, stable in time and with no circadian variations is a useful parameter for diagnosing growth hormone deficit. The IGFBP3 was evaluated using sera, collected and kept at -20 degrees C, from subjects classified according to auxologic characters and response sup. or inf. to 8 ng/ml GH after two stimulation tests and median nocturnal GH sup. or inf. to 3 ng/ml. Two groups were studied: 1) Small stature GHD (growth hormone deficiency): 14 cases; 2) Constitutional small stature (RCC,BSF): 12 cases. A third group composed of 8 normal height, weight and disease-free children formed the control group. The IGFBP3 values were below the 5th percentile in 86% of GHD cases, between the 5th and 95th percentile in 66.6% of constitutionally short stature children and in all normal controls was about the 50th percentile. The IGFBP3 also shows a statistically significant correlation between median nocturnal GH, both in deficient and constitutionally short stature groups (p0.01). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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