Impact of preconditioned diabetic stem cells and photobiomodulation on quantity and degranulation of mast cells in a delayed healing wound simulation in type one diabetic rats

Autor: Houssein, Ahmadi, Mohammad, Bayat, Abdollah, Amini, Atarodalsadat, Mostafavinia, Roohollah, Ebrahimpour-Malekshah, Rouhallah, Gazor, Robabeh, Asadi, Latif, Gachkar, Fatemehalsadat, Rezaei, Sasha H, Shafikhani, Seyed Kamran, Ghoreishi, Sufan, Chien
Rok vydání: 2021
Předmět:
Zdroj: Lasers in medical science. 37(3)
ISSN: 1435-604X
Popis: Herein, we report the influence of administering different protocols of preconditioned diabetic adipose-derived mesenchymal stem cells (ADSs) with photobiomodulation in vitro, and photobiomodulation in vivo on the number of mast cells (MCs), their degranulation, and wound strength in the maturation step of a Methicillin-resistant Staphylococcus aureus (MRSA)-infectious wound model in rats with type one diabetes. An MRSA-infectious wound model was generated on diabetic animals, and they were arbitrarily assigned into five groups (G). G1 were control rats. In G2, diabetic ADS were engrafted into the wounds. In G3, diabetic ADS were engrafted into the wound, and the wound was exposed to photobiomodulation (890 nm, 890 ± 10 nm, 80 Hz, 0.2 J/cm
Databáze: OpenAIRE