[Long-term potentiation of AMPA- and NMDA-components of minimal postsynaptic currents in CA1 area of the rat hippocampus]

Autor:	I T, Baiazitov, L L, Voronin, A M, Kas'ianov, A M, Kleshchevnikov, S V, Kul'chitskiĭ, E A, Sametskiĭ
Rok vydání:	2001
Předmět:	Patch-Clamp Techniques Long-Term Potentiation Synapses Animals Receptors AMPA In Vitro Techniques Rats Wistar Excitatory Amino Acid Antagonists Hippocampus Receptors N-Methyl-D-Aspartate Electric Stimulation Rats
Zdroj:	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 87(4)
ISSN:	0869-8139
Popis:	Excitatory postsynaptic currents (EPSC) were recorded from pyramidal neurons of the rat hippocampal slices as well as the AMPA and NMDA components. A strong enough correlation between the amplitudes of the components provided a reliable evidence of their generation by the same synapse. Both components revealed similar LTP following afferent tetanisation. The data obtained do not support postsynaptic mechanisms of the LTP maintenance but suggest that increased presynaptic release represents a basic mechanism of the early LTP maintenance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::259b53c183b9905ebfbb0e9553216dae https://pubmed.ncbi.nlm.nih.gov/11449972 Zobrazit plný text záznamu