Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Autor:	Nadia K, Magdalinou, Hannah L, Golden, Jennifer M, Nicholas, Pirada, Witoonpanich, Catherine J, Mummery, Huw R, Morris, Atbin, Djamshidian, Tom T, Warner, Elizabeth K, Warrington, Andrew J, Lees, Jason D, Warren
Rok vydání:	2018
Předmět:	Male Verbal Behavior Brain progressive supranuclear palsy Neuropsychological Tests Lewy body disease dynamic aphasia behavioral disciplines and activities Speech Disorders Article nervous system diseases Parkinsonian Disorders Parkinson’s disease Humans Female Aged corticobasal degeneration
Zdroj:	Neurocase
ISSN:	1465-3656
Popis:	Verbal adynamia (impaired language generation, as during conversation) has not been assessed systematically in parkinsonian disorders. We addressed this in patients with Parkinson’s dementia, progressive supranuclear palsy and corticobasal degeneration. All disease groups showed impaired verbal fluency and sentence generation versus healthy age-matched controls, after adjusting for general linguistic and executive factors. Dopaminergic stimulation in the Parkinson’s group selectively improved verbal generation versus other cognitive functions. Voxel-based morphometry identified left inferior frontal and posterior superior temporal cortical correlates of verbal generation performance. Verbal adynamia warrants further evaluation as an index of language network dysfunction and dopaminergic state in parkinsonian disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::253d2c4f4006ca72f353c95163e9945b https://pubmed.ncbi.nlm.nih.gov/30293517 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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