Efficacy of BCG Vaccination Depends on Host Genetics

Autor:	B V, Nikonenko, N N, Logunova, N V, Sterzhanova, S I, Kayukova, A S, Apt
Rok vydání:	2021
Předmět:	Mice Inbred C57BL Mice Mice Inbred AKR Mice Inbred BALB C Host-Pathogen Interactions Vaccination BCG Vaccine Animals Tuberculosis Vaccine Efficacy Female Mycobacterium tuberculosis Genetic Background
Zdroj:	Bulletin of experimental biology and medicine. 171(4)
ISSN:	1573-8221
Popis:	We studied the effectiveness of anti-tuberculosis vaccination with BCG in mice of inbred strains and F1 hybrids (highly resistant to tuberculosis infection) that represent a wide range of genetically determined differences in susceptibility to infection with virulent Mycobacterium tuberculosis. The greatest relative effect was found in susceptible mice, with the exception of highly susceptible I/St mice that were practically not protected by vaccination. Despite significant effect of vaccination in inbred mice, their resistance to M. tuberculosis infection did not exceed that of non-vaccinated highly resistant F1 hybrids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::253b6182c8e61265068073f54e0025aa https://pubmed.ncbi.nlm.nih.gov/34542757 Zobrazit plný text záznamu Full text from SpringerLink