| Autor: |
Luca, Bertinotti, Marzia, Mortilla, Maria Letizia, Conforti, Nicola, Colangelo, Francesca, Nacci, Angela, Del Rosso, Claudio, Fonda, Roberto, Casale, Marco, Matucci-Cerinic, Alberto, Pignone |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
The Journal of rheumatology. 33(3) |
| ISSN: |
0315-162X |
| Popis: |
Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy (1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc.N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects.With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p0.02) and at RCS (p0.002) was detected in SSc patients. Cho/Cr ratio was increased (p0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG.Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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