| Autor: |
Jonathan A, Swain, Stephen R, Walker, Matthew B, Calvert, Margaret A, Brimble |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Natural product reports. 39(2) |
| ISSN: |
1460-4752 |
| Popis: |
Covering: from 1938 up to March 2021The electron-rich indole side chain of tryptophan is a versatile substrate for peptide modification. Upon the action of various cyclases, the tryptophan side chain may be linked to a nearby amino acid residue, opening the door to a diverse range of cyclic peptide natural products. These compounds exhibit a wide array of biological activity and possess fascinating molecular architectures, which have made them popular targets for total synthesis studies. This review examines the isolation and bioactivity of tryptophan-linked cyclic peptide natural products, along with a discussion of their first total synthesis, and biosynthesis where this has been studied. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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