| Autor: |
H B, Hucker, A J, Balletto, J, Demetriades, B H, Arison, A G, Zacchei |
| Rok vydání: |
1977 |
| Předmět: |
|
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals. 5(2) |
| ISSN: |
0090-9556 |
| Popis: |
Dogs excreted approximately 45% of an oral dose of 14C-amitriptyline (30 mg/kg) in the urine in 24 hr. Two new urinary metabolites of the drug were identified as dihydrodiol derivatives of amitriptyline and nortriptyline, respectively. The major metabolite in dog urine was 10-hydroxyamitriptyline, excreted mainly in conjugated form. Other metabolites were characterized as 10-hydroxynortriptyline, amitriptyline N-oxide, and nortriptyline. Together, these metabolites accounted for approximately 47% of the urinary radioactivity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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