Enzyme-catalyzed asymmetric deacylation for the preparation of lasofoxifene (CP-336156), a selective estrogen receptor modulator

Autor:	X, Yang, A R, Reinhold, R L, Rosati, K K, Liu
Rok vydání:	2000
Předmět:	Selective Estrogen Receptor Modulators Pyrrolidines Tetrahydronaphthalenes X-Ray Diffraction Dealkylation Hydrolysis Stereoisomerism Catalysis
Zdroj:	Organic letters. 2(25)
ISSN:	1523-7060
Popis:	[structure] selective estrogen receptor modulator (SERM), Lasofoxifene (CP-336156), was prepared by an enzyme-catalyzed asymmetric deacylation with high optical purity and excellent yield even though the hydrolytic site is remote from the chiral centers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::24ec5189f61b7aa24333c6c067257a9a https://pubmed.ncbi.nlm.nih.gov/11112634 Zobrazit plný text záznamu