| Autor: |
J, Vakkilainen, K V, Porkka, I, Nuotio, P, Pajukanta, L, Suurinkeroinen, K, Ylitalo, J S, Viikari, C, Ehnholm, M R, Taskinen |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
European journal of clinical investigation. 28(1) |
| ISSN: |
0014-2972 |
| Popis: |
Familial combined hyperlipidaemia (FCHL) is a common hereditary disorder. Hypertriglyceridaemia is associated with glucose intolerance and insulin resistance.To study glucose tolerance in FCHL patients with different lipid phenotypes [hypercholesterolaemia (IIA), mixed hyperlipidaemia (IIB), hypertriglyceridaemia (IV)], we investigated 253 family members and 92 spouses arising from 33 well-defined Finnish FCHL pedigrees.In oral glucose tolerance tests the affected family members had higher values for glucose area under the curve than did non-affected family members [673+/-127 min mmolL(-1), 754+/-145 min mmol L(-1), 846+/-180 min mmol L(-1) and 838+/-183 min mmol L(-1) for phenotypes normal, IIA, IIB and IV respectively; P0.001 after adjustment for body mass index, waist circumference and age]. Impaired glucose tolerance and diabetes were more common among affected than non-affected family members (prevalences of normal glucose tolerance 94.0%, 80.0%, 54.3% and 58.5% for phenotypes normal, IIA, IIB and IV).Affected FCHL family members were more glucose intolerant than non-affected family members. In men, this disturbance was not related to lipid phenotype nor was it explained by obesity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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