[Therapeutic advances in breast cancer]
| Autor: | B C, Pestalozzi |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Time Factors Antineoplastic Agents Hormonal Aromatase Inhibitors Receptor ErbB-2 Sentinel Lymph Node Biopsy Antibodies Monoclonal Antineoplastic Agents Breast Neoplasms Middle Aged Trastuzumab Antibodies Monoclonal Humanized Prognosis Postmenopause Chemotherapy Adjuvant Antineoplastic Combined Chemotherapy Protocols Humans Female Breast RNA Messenger RNA Neoplasm Neoplasm Staging |
| Zdroj: | Therapeutische Umschau. Revue therapeutique. 63(4) |
| ISSN: | 0040-5930 |
| Popis: | The treatment of breast cancer has made significant improvements during the past ten years. For early breast cancer with a clinically negative axilla sentinel node biopsy has become the preferred approach. For endocrine therapy of postmenopausal patients the selective aromatase inhibitors have become standard in metastatic as well as in early breast cancer. Trastuzumab (Herceptin) plays an important role in the treatment of HER2-positive breast cancer in the metastatic and since 2005 also in the adjuvant setting. When chemotherapy is used to treat metastatic breast cancer drug combinations are superior to monotherapy only in terms of response rates. By contrast, in the adjuvant setting combination drug therapy is the standard. New methods of tissue analysis including expression patterns of mRNA and proteins are promising research strategies to further advance the field. |
| Databáze: | OpenAIRE |
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