Prospectively randomized trial of adjuvant active-specific immunotherapy for human colorectal cancer

Autor:	H C, Hoover, M G, Surdyke, R B, Dangel, L C, Peters, M G, Hanna
Rok vydání:	1985
Předmět:	Adult Male Clinical Trials as Topic Rectal Neoplasms Middle Aged Combined Modality Therapy Specimen Handling Random Allocation Colonic Neoplasms BCG Vaccine Humans Female Immunotherapy Neoplasm Recurrence Local Aged
Zdroj:	Cancer. 55(6)
ISSN:	0008-543X
Popis:	Over the last four years a guinea pig model of active-specific immunotherapy (ASI) with a syngeneic tumor cell:bacillus calmette-Guerin (BCG) vaccine was translated into a prospectively randomized, controlled clinical trial in patients with colorectal cancer. Primary tumors from patients undergoing standard surgical resection were dissociated enzymatically and cryopreserved by techniques that maintain cell viability. Patients with transmural extension of tumor or nodal metastases were randomized into groups treated by resection alone (control) or resection plus ASI. With a mean follow-up of 28 months (range, 14-24), only 3 of 20 treatment patients had recurrences and none have died, whereas 9 of 20 control patients had recurrences and 4 died. These differences are statistically significant and are sufficiently encouraging to warrant expansion of these studies into other research centers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::24b39077bddfe554ad725e5a61e23a46 https://pubmed.ncbi.nlm.nih.gov/3882219 Zobrazit plný text záznamu Plný text