Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in Aβ

Autor:	Xia, Jiang, Lin-Lin, Chen, Zhou, Lan, Fan, Xiong, Xiang, Xu, Yang-Yang, Yin, Ping, Li, Ping, Wang
Rok vydání:	2019
Předmět:	Flavonoids Male Amyloid beta-Peptides Hippocampus Peptide Fragments Injections Rats Sprague-Dawley Neuroprotective Agents Alzheimer Disease Macroautophagy Animals Homeostasis Humans Lysosomes Maze Learning Spatial Memory
Zdroj:	Neurochemical research. 44(12)
ISSN:	1573-6903
Popis:	Macroautophagy, a sole pathway for dysfunctional organelles or aggregated proteins turnover, has been implicated in the early development of Alzheimer's disease (AD). Previous studies have found that reversal of autophagy dysfunction in APP transgenic mice ameliorates amyloid pathologies. Icariin (ICA), the main component from traditional Chinese herb Epimedium brevicornu Maxim., can reduce accumulations of amyloid-β (Aβ) peptide in vivo and in vitro, but the mechanism remains unclear. Here, we explored the effects of ICA on autophagy-lysosomal pathway in intracerebroventricular (icv) injection of human Aβ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::24a812724c3ec4b4eb960cbd1688be43 https://pubmed.ncbi.nlm.nih.gov/31612304 Zobrazit plný text záznamu Full text from SpringerLink