Effects of daunomycin and its macromolecular analog daunophilin on the proliferation of mammalian cells

Autor:	J, Keprtová, M, Vyhnáková, E, Minárová, V, Kleinwächter
Rok vydání:	1993
Předmět:	Time Factors Dose-Response Relationship Drug Daunorubicin Molecular Sequence Data Glioma Cell Line Rats Tumor Cells Cultured Animals Humans Methacrylates Female Amino Acid Sequence Lung Cell Division HeLa Cells
Zdroj:	Neoplasma. 40(3)
ISSN:	0028-2685
Popis:	Effects of daunomycin and daunomycin bound to an HPMA copolymer (daunophilin) on the proliferation of mammalian cells cultivated in vitro were compared. One line of non-tumor cells (LEP human cells) and two tumor cell lines (human HeLa cells and C6 rat cells) were used. It was found that both daunomycin and daunophilin had an inhibitory effect on the proliferation of the three cell lines and that the effect was irreversible. Daunophilin had to be used in concentrations by two orders of magnitude higher (1 micrograms/ml) than daunomycin (0.01 micrograms/ml) to produce comparable effect on cell growth.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::249ae226dc83194ce300c0c7309337e9 https://pubmed.ncbi.nlm.nih.gov/8350963 Zobrazit plný text záznamu