Cytochrome P450 2C19 inhibitory activity of common berry constituents

Autor:	Philipp G, Sand, Andrea, Dreiseitel, Martin, Stang, Peter, Schreier, Anett, Oehme, Sanja, Locher, Goeran, Hajak
Rok vydání:	2009
Předmět:	Anthocyanins Cytochrome P-450 CYP2C19 Food-Drug Interactions Inhibitory Concentration 50 Fluvoxamine Fruit Luminescent Measurements Humans Proanthocyanidins Aryl Hydrocarbon Hydroxylases Enzyme Inhibitors
Zdroj:	Phytotherapy research : PTR. 24(2)
ISSN:	1099-1573
Popis:	The cytochrome P450 enzyme CYP2C19 is involved in the metabolism of many commonly prescribed drugs, including proton pump inhibitors, antiepileptics and antidepressants. CYP2C19 inhibitors from food and food supplements may augment the toxicity of these agents and lead to noncompliance with treatment. The present investigation addresses CYP2C19 inhibition by 18 berry constituents using a chemiluminescent assay. Test compounds displayed inhibitory properties in a concentration-dependent fashion, with IC(50) values ranging from 20.2 microM up to316 microM. In the order of decreasing effect size, anthocyanidins were followed by anthocyanidin-monoglycosides and procyanidins. Anthocyanidin-diglucosides exhibited weak and biphasic effects. When compared with the CYP2C19 inhibitor fluvoxamine, the flavonoids under study were 50- to 750-fold less potent. It is concluded that the above natural substances are moderate to poor inhibitors of CYP2C19 in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::244aef22e59ee6e5a09f756b1865efad https://pubmed.ncbi.nlm.nih.gov/19585468 Zobrazit plný text záznamu Plný text