[Review of findings on binding of tricyclic antidepressants]

Autor:	R, Krulík, Z, Fisar
Jazyk:	čeština
Rok vydání:	1993
Předmět:	Blood Platelets Depressive Disorder Binding Sites Animals Brain Humans Antidepressive Agents Tricyclic
Zdroj:	Ceskoslovenska psychiatrie. 89(2)
ISSN:	0069-2336
Popis:	Authors summarize knowledge in the field of the high-affinity binding of tricyclic antidepressants on cell membranes within last 12 years. Some ideas about the significance of such binding are stated. Both the data from papers and our knowledge are discussed with regard to the possibility of their clinical application at depressed patients. Effects of the tricyclic antidepressants are linked with their influence on the active transport of neuromediators through the cell membrane but their molecular mechanisms are unknown. Present-day state of research is described and the orientation on the role of membrane phospholipids in the binding studies of the tricyclic antidepressants is emphasized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::241170872518c55abea36f2503b0ed0f https://pubmed.ncbi.nlm.nih.gov/8403025 Zobrazit plný text záznamu