| Autor: |
Ulrike, Luderer, Jinhwan, Lim, Laura, Ortiz, Johnny D, Nguyen, Joyce H, Shin, Barrett D, Allen, Lisa S, Liao, Kelli, Malott, Veronique, Perraud, Lisa M, Wingen, Rebecca J, Arechavala, Bishop, Bliss, David A, Herman, Michael T, Kleinman |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Particle and Fibre Toxicology |
| ISSN: |
1743-8977 |
| Popis: |
Background Fine particulate matter (PM2.5) exposure accelerates atherosclerosis and contains known ovotoxic chemicals. However, effects of exposure to PM2.5 on the finite ovarian follicle pool have hardly been investigated, nor have interactions between ovarian and cardiovascular effects. We hypothesized that subchronic inhalation exposure to human-relevant concentrations of PM2.5 results in destruction of ovarian follicles via apoptosis induction, as well as accelerated recruitment of primordial follicles into the growing pool. Further, we hypothesized that destruction of ovarian follicles enhances the adverse cardiovascular effects of PM2.5 in females. Results Hyperlipidemic apolipoprotein E (Apoe) null ovary-intact or ovariectomized female mice and testis-intact male mice were exposed to concentrated ambient PM2.5 or filtered air for 12 weeks, 5 days/week for 4 h/day using a versatile aerosol concentration enrichment system. Primordial, primary, and secondary ovarian follicle numbers were decreased by 45%, 40%, and 17%, respectively, in PM2.5-exposed ovary-intact mice compared to controls (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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