New bis(dithiocarboxylato) nitridotechnetium-99m radiopharmaceuticals for leucocyte labelling: in vitro and in vivo studies

Autor:	F, Demaimay, N, Noiret, A, Roucoux, H, Patin, E, Bellande, R, Pasqualini, A, Moisan
Rok vydání:	1997
Předmět:	Inflammation Male Solubility Isotope Labeling Leukocytes Animals Humans Organotechnetium Compounds Ligands Radionuclide Imaging Papio
Zdroj:	Nuclear medicine and biology. 24(5)
ISSN:	0969-8051
Popis:	Dithiocarboxylate ligands were synthesized and characterised. New nitrido 99m-technetium complexes were obtained with these ligands and identified by thin layer chromatography. The nitrido complexes were tested in vitro in whole blood for leucocyte labelling and the design of the ligand was optimized. Best results were obtained with aliphatic linear ligands, containing 9 to 11 atoms of carbon. The in vivo experiment failed because an inflammated area could not be visualized by gamma imaging, the cell labelling mechanism being probably different.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::23c10979fb198cfda3230f18cf12f60b https://pubmed.ncbi.nlm.nih.gov/9290080 Zobrazit plný text záznamu Full Text from ScienceDirect