| Autor: |
Cengiz, Bölükbaş, Füsun F, Bölükbaş, Oya, Ovünç, Güray, Kiliç, Remzi, Dalay, Hatice, Güven, Fikriye, Uras, Turay K, Yardimci, Mehmet H, Sökmen, Ahmet F, Agan, Nezih, Pişkinpaşa |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 17(3) |
| ISSN: |
1300-4948 |
| Popis: |
Serum pepsinogen levels are considered as a non-endoscopic blood test in the diagnosis of atrophic gastritis. The objective of the present study was to investigate whether there is any difference between pepsinogen levels in Helicobacter pylori-positive and -negative patients with atrophic gastritis, and to analyze the relationship between histopathology and pepsinogen levels after treatment in H. pylori-positive patients with atrophic gastritis.The study enrolled a total of 30 cases with atrophic gastritis (18 H. pylori-positive and 12 H. pylori-negative). The H. pylori-positive cases received a one-week eradication treatment. Initially for all and after the treatment for H. pylori-positive cases, serum pepsinogen I and II levels, anti-H. pylori IgG titration and histopathologic analysis were carried out.In the H. pylori-positive patients with atrophic gastritis, the levels of pepsinogen I and pepsinogen I/II ratio were lower while the levels of pepsinogen II were higher compared to the H. pylori-negative patients (p0.05 for all). The post-treatment serum pepsinogen I levels and pepsinogen I/II ratios did not change in the H. pylori-positive group, while the levels of pepsinogen II, H. pylori antibody titration and gastric atrophy degree remarkably decreased (p0.05 for all).In atrophic gastritis, the levels of serum pepsinogen and pepsinogen I/II ratio show a difference in H. pylori-negative versus -positive cases. Additionally, the usage of pepsinogen II as a serum marker in predicting the eradication of H. pylori with atrophic gastritis could be more reliable than pepsinogen I or the I/II ratio. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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