| Autor: |
L, Gladieff, E, Chatelut, M H, Gaspard, R, Skaf, M, de Forni, J, Mihura, P, Canal, R, Bugat |
| Jazyk: |
francouzština |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Bulletin du cancer. 86(7-8) |
| ISSN: |
0007-4551 |
| Popis: |
Consolidation treatment of advanced ovarian carcinoma, especially the place of intraperitoneal chemotherapy, remains a controversial subject. From January 1988 to July 1995, 39 patients, median age 54 years, received intraperitoneal chemotherapy as consolidation treatment after second-look surgery. At the time of intraperitoneal chemotherapy, 30 patients had no residual disease. Intraperitoneal drug administration used a Tenckoff catheter or a lumbar needle. Treatment combined 5 fluorouracil 1 g/m2 and cisplatin 200 mg/m2, associated with a systemic sodium thiosulfate rescue as nephroprotector. A pharmacological analysis was done for 9 patients: the exposure of peritoneal cavity to cisplatin exceeded that of the plasma by 11 fold. Hematologic and nephrologic toxicity were acceptable. The median follow-up is 43 months. The disease free survival is 36,6 months, but 48,5 months if no residual disease at the time of intraperitoneal chemotherapy. Consolidation treatment by intense intraperitoneal chemotherapy is a feasible approach and might be beneficial in chemosensitive patients devoid of macroscopic remnants, but must be compared with others approaches. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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