[IgG autoantibodies against cellular p72 antigen crossing with (MLV) p15-gag antigen: presence in early HIV 1 infection, in HBV infection and in primary Gougerot-Sjögren]

Autor:	M, Rucheton, I, Stefas, I, Lamaury, J, Coste, J, Reynes, J M, Lemaire, H, Graafland
Jazyk:	francouzština
Rok vydání:	1992
Předmět:	Acquired Immunodeficiency Syndrome Sjogren's Syndrome Immunoglobulin G HIV-1 Gene Products gag Humans Lupus Erythematosus Systemic Cross Reactions Hepatitis B Antigens Viral Autoantibodies HeLa Cells
Zdroj:	Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 314(12)
ISSN:	0764-4469
Popis:	IgG antibodies of autoimmune SLE (Systemic Lupus Erythematosus) serum S detected a HeLa hnRNP 72 kDa protein, cross-reacting with the retroviral (MLV) p15-gag polypeptide. Since serum S disclosed a ubiquitous 72 kDa antigen in HeLa cell fractions, was prepared the so-called cytoplasmic "X fraction", enriched for the 72 kDa protein, defined here as p72. This autoantigen was detected by antibodies of HIV 1+ patients, recently of seroconverted (RSC) asymptomatic subjects, of HBV+ sera, and of primary Gougerot-Sjögren (prGS) sera. The presence of these autoantibodies in different autoimmune and infectious pathologies raises the question of the involvement of p72 in the immune processes and in the early HIV1 infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::238cdbfa4ca836b89dc07ca901ffd436 https://pubmed.ncbi.nlm.nih.gov/1521174 Zobrazit plný text záznamu