Mixed-type autoimmune hemolytic anemia following fludarabine treatment in a patient with chronic lymphocytic leukemia/small cell lymphoma

Autor:	D J, Vick, J C, Byrd, C L, Beal, D J, Chaffin
Rok vydání:	1998
Předmět:	Coombs Test Temperature Humans Antineoplastic Agents Female Anemia Hemolytic Autoimmune Middle Aged Leukemia Lymphocytic Chronic B-Cell Vidarabine Autoantibodies
Zdroj:	Vox sanguinis. 74(2)
ISSN:	0042-9007
Popis:	Mixed-type autoimmune hemolytic anemia (AIHA) is a rare complication of chronic lymphocytic leukemia (CLL). We report a patient with small lymphocytic lymphoma (phenotypic CLL) who developed symptomatic anemia 3 weeks after her fifth cycle of fludarabine, a T cell immunosuppressant.An antibody screen and panel, direct antiglobulin test, rapid acid eluate, rabbit erythrocyte stroma (RESt) adsorption, and autoadsorption were performed.Warm and cold autoantibodies were detected. prompt treatment with corticosteroids and minimal blood transfusions led to marked improvement.Normally, T cells suppress polyclonal lymphocytes that produce autoantibodies. Suppression of T cells in this patient, in addition to the underlying disease process, may explain this mixed-type AIHA, the first reported case to occur following fludarabine treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::23663f9095283b44bd86bc4ba0a61537 https://pubmed.ncbi.nlm.nih.gov/9501412 Zobrazit plný text záznamu Plný text