Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions

Autor:	N, Ni, M M, El-Sayed, T, Sanghvi, S H, Yalkowsky
Rok vydání:	2000
Předmět:	Solutions Kinetics Octanols Chemical Phenomena Solubility Chemistry Physical Solvents Water Organic Chemicals Sodium Chloride Chromatography High Pressure Liquid
Zdroj:	Journal of pharmaceutical sciences. 89(12)
ISSN:	0022-3549
Popis:	The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::23595c6bcd7a75c7d7ff88cdb65566f7 https://pubmed.ncbi.nlm.nih.gov/11042610 Zobrazit plný text záznamu Plný text