Transient elastography and portal hypertension in pediatric patients with cystic fibrosis Transient elastography and cystic fibrosis

Autor:	A C, Malbrunot-Wagner, L, Bridoux, J B, Nousbaum, C, Riou, A, Dirou, J L, Ginies, C, Maurage, B, Cagnard, C, Pelatan, A, Dabadie
Rok vydání:	2010
Předmět:	Male Adolescent Cystic Fibrosis Platelet Count Esophageal and Gastric Varices Severity of Illness Index Predictive Value of Tests Hypertension Portal Disease Progression Elasticity Imaging Techniques Humans Female Child Retrospective Studies
Zdroj:	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 10(5)
ISSN:	1873-5010
Popis:	Esophageal varices (EV) are a complication of cystic fibrosis-associated liver disease. Esophagogastroduodenoscopy (EGD) is currently used to diagnose varices but is invasive for pediatric patients. The goal of this study was to explore the relationship between transient elastography (FibroScan®) and the presence of EV in patients with liver disease defined by clinical, laboratory, sonographic, and/or endoscopic criteria.18 patients with cystic fibrosis underwent EGD and transient elastography. 12 patients had EV.Patients with EV had higher FibroScan values than those without varices with median values of 22.4 kPa (14.4-30.4 kPa) vs. 7.9 kPa (4.4-13.7 kPa) (p=0.01). Using a threshold of 12 kPa, four of six patients without EV would not have needed EGD.Elastography should be recommended for all cystic fibrosis patients with liver disease to follow its progression. A prospective study is needed to define an elastography threshold value that predicts the presence of EV.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2302d2275c5b78955e756ad136e02b26 https://pubmed.ncbi.nlm.nih.gov/21550861 Zobrazit plný text záznamu Full Text from ScienceDirect