Heavy-Metal Trojan Horse: Enterobactin-Directed Delivery of Platinum(IV) Prodrugs to

Autor:	Chuchu, Guo, Elizabeth M, Nolan
Rok vydání:	2023
Předmět:	HEK293 Cells Escherichia coli Humans Siderophores Prodrugs Cisplatin Escherichia coli Infections Anti-Bacterial Agents Enterobactin Platinum
Zdroj:	Journal of the American Chemical Society. 144(28)
ISSN:	1520-5126
Popis:	The global crisis of untreatable microbial infections necessitates the design of new antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire. In this study, we repurpose the clinically approved anticancer agent cisplatin into a targeted antibiotic by conjugating its Pt(IV) prodrug to enterobactin (Ent), a triscatecholate siderophore employed by Enterobacteriaceae for iron (Fe) acquisition. The l-Ent-Pt(IV) conjugate (l-EP) exhibits antibacterial activity against
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::22f6128acbcbbbacb0e75ee58b5f55dc https://pubmed.ncbi.nlm.nih.gov/35803281 Zobrazit plný text záznamu