| Autor: |
L I, Ol'binskaia, S A, Golubev, T D, Bol'shakova, G V, Anastas'ina, A F, Buniatian, A A, Nosova |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Terapevticheskii arkhiv. 67(9) |
| ISSN: |
0040-3660 |
| Popis: |
Changes in arterial hypertension, heart rate and adrenocortical hormones (11-OCS, aldosteron, progestins) in the blood and 24-h urine were followed up in the course of 24-week use of angiotensin-converting enzyme inhibitor benazepril (10-20 mg once a day) in 24 patients with mild and moderate essential hypertension (EH) included in a placebo-controlled randomized study. A 2 and 24-week antihypertensive response was achieved in 75 and 71% of patients, respectively. 24-h urinary excretion of corticosteroids before the treatment was increased. After the treatment benazepril reduced excretion of 11-OCS by 42%, but not of aldosteron the levels of which decreased only within the first 2 weeks of treatment. The above trends in changes of gluco- and mineralocorticoid activity should be taken into consideration in long-term treatment of EH with inhibitors of angiotensin-converting enzyme. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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