| Autor: |
Rosane Dias, Costa, Vanessa Amaral, Mendonça, Sandra, Lyon, Rachel Adriana, Penido, Ana Maria Duarte Dias, Costa, Marina Dias, Costa, Marina Pires, Nishi, Mauro Martins, Teixeira, Antônio Lúcio, Teixeira, Carlos Maurício de Figueiredo, Antunes |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Revista da Sociedade Brasileira de Medicina Tropical. 41 |
| ISSN: |
1678-9849 |
| Popis: |
Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1beta and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT), and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1beta. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
